Frontispiece: Dibenzo[ a , e ]pentalenophanes: Bending a Non‐Alternant Hydrocarbon
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چکیده
منابع مشابه
Metabolic activation of dibenzo(a,e)fluoranthene, a nonalternant carcinogenic polycyclic hydrocarbon, in liver homogenates.
Dibenzo(a,e)fluoranthene (DBF), a powerful carcinogenic nonalternant aromatic hydrocarbon, has been metabolized in vitro by incubation in mouse and rat liver microsomal homogenates. Five major stable metabolites were separated by highpressure liquid chromatography and then analyzed by spectroscopic procedures and comparison with synthetic model com pounds. Three of them are phenols correspondin...
متن کاملBreakdown of interference rules in azulene, a nonalternant hydrocarbon.
We have designed and synthesized five azulene derivatives containing gold-binding groups at different points of connectivity within the azulene core to probe the effects of quantum interference through single-molecule conductance measurements. We compare conducting paths through the 5-membered ring, 7-membered ring, and across the long axis of azulene. We find that changing the points of connec...
متن کاملSynthesis and Reactions of Dibenzo[a, e]pentalenes
Pentalene has recently received a considerable amount of attention as a ligand in sandwich-type transition metal complexes. In contrast, dibenzo[a,e]pentalene (hereafter denoted as dibenzopentalene), which is more -extended than pentalene, has received less attention, despite its potential usefulness as a building block of ladder-type -conjugated molecules, which have recently received growin...
متن کاملBinding of dibenzo(a,e)fluoranthene, a carcinogenic, polycyclic hydrocarbon without K-region, to nucleic acids in a subcellular microsomal system.
Dibenzo(a,e)fluoranthene (DBF), a highly carcinogenic polycyclic hydrocarbon without an apparent K-region, binds covalently to DNA, transfer RNA, and polyribonucleotides when incubated with hepatic microsomal fractions under standard conditions. Optimal binding conditions for [3H]DBF were established. Methylcholanthrene-pretreated mouse liver microsomes induced a higher level of binding of [3H]...
متن کاملBinding of Dibenzo(a,e)fluoranthene, a Carcinogenic, Polycyclic Hydrocarbon without K-Region, to Nucleic Acids in a Subcellular Microsomal System1
Dibenzo(a,e)fluoranthene (DBF), a highly carcinogenic polycyclic hydrocarbon without an apparent K-region, binds covalently to DNA, transfer RNA, and polyribonucleotides when incubated with hepatic microsomal frac tions under standard conditions. Optimal binding condi tions for [3H]DBF were established. Methylcholanthrene-pretreated mouse liver microsomes induced a higher level of binding of [ ...
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ژورنال
عنوان ژورنال: Chemistry – A European Journal
سال: 2018
ISSN: 0947-6539,1521-3765
DOI: 10.1002/chem.201882965